Summary: The combination of pamapimod and pioglitazone (KIN001) has a synergetic antiviral, anti-inflammatory, and antifibrotic activity, which may prevent evolution toward COVID-19-associated severe respiratory failure.In a randomized, placebo-controlled, double-blind, phase 2, multicenter trial, 128 non-critically ill hospitalized patients with c
Operation mode is widely used in a refinery production process, bringing great convenience to its daily operations.However, the refinery scheduling model with operation mode makes the scheduling model become large and thus difficult to solve.In this article, we present a new refinery scheduling model based on Variable Driven Modelling SPOON (VDM) a
Background: Propionic acidemia Play Dough (PA) is an inborn error of metabolism (IEM) that typically presents in the newborn.The Amish of North America have an increased prevalence of PA due to a founder variant in the PCCB gene.The Amish PA phenotype is variable, and some individuals remain asymptomatic and undiagnosed until adulthood.Additionally
OBJECTIVE: To estimate the cost of scaling up childhood immunization services required to reach the WHO-UNICEF Global Immunization Vision and Strategy (GIVS) goal of reducing mortality due to vaccine-preventable diseases by two-thirds by 2015.METHODS: A model was developed to estimate the total cost of reaching GIVS goals by 2015 in 117 low- and lo
Musculoskeletal injuries and chronic degenerative diseases commonly affect both athletic and sedentary horses and can entail the end of their athletic careers.The ensuing repair processes frequently do not yield fully functional regeneration of the injured tissues but biomechanically Glasses and Goggles inferior scar or replacement tissue, causing